Small Protein, Big Impact: Microprotein Discovery Offers Hope for Obesity and Aging

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Researchers have uncovered a tiny but powerful protein that helps keep our cells’ energy factories humming – a discovery that could spark new approaches to tackling obesity and age-related decline. Scientists at the Salk Institute in La Jolla found that a  “microprotein”  in mouse fat cells plays a critical role in maintaining healthy  mitochondria , the structures that generate energy in our cells. By preserving mitochondrial function, this diminutive protein helps cells burn fuel efficiently, which in turn could influence body weight and the aging process. The findings shine light on how molecular biology connects to everyday health, opening the door to  science-backed strategies for better metabolism and longevity. Mature brown fat cells from a mouse, with the newly discovered microprotein shown in red inside mitochondria (green) and nuclei in blue. This tiny protein helps preserve mitochondrial health under stress. (Credit: Salk Institute) Mighty Mitochondria in ...

Poorer Movement Skills at Seven Months in Children at Risk of Autism

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Poorer movement skills detected as early as 7 months old are observed in children at a higher risk of developing Autistic Spectrum Disorder (ASD) than children in the general population. These are the findings of a study being presented on 7th September 2011 at the British Psychological Society's Developmental Section Conference in Newcastle.

The study was carried out by a team led by Dr. Elisabeth Hill at Goldsmiths (University of London), Dr. Hayley Leonard (Goldsmiths) and the British Autism Study of Infant Siblings (BASIS) based at Birkbeck University of London. The researchers examined infants with a diagnosed older sibling with ASD. Siblings are known to share a higher risk of developing the disorder.

The researchers assessed the infants using a longitudinal follow-up design at 7, 14, and 24 months. Two groups of infants participated in the study: (1) 54 infants at-risk of a diagnosis of ASD based on a sibling diagnosis and (2) 50 low-risk infants without a diagnosed sibling. The infants were assessed on a range of standardised measures of motor skills. Parent reports were also documented.

Statistical analyses revealed that the at-risk group had significantly poorer motor skills than the low-risk group detected as early as 7 months old. Both gross motor skills such as the ability to hold up the head/roll over/walk and fine motor skills such as grasping and manipulating small objects were found to be poorer in the group of children at-risk for the disorder. This poorer motor ability was still evident at the 24 month assessment stage..

Dr. Hayley Leonard, the presenter of the study findings at the conference said "These data are extremely important because even if the at-risk infants do not go on to be diagnosed with ASD, research suggests that poorer motor development could have a negative impact on their language, social and cognitive development over time. This poorer motor development could impact on their development of social skills, school achievement and longer-term employment outcomes."

Source: British Psychological Society (BPS), via AlphaGalileo.

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