Small Protein, Big Impact: Microprotein Discovery Offers Hope for Obesity and Aging

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Researchers have uncovered a tiny but powerful protein that helps keep our cells’ energy factories humming – a discovery that could spark new approaches to tackling obesity and age-related decline. Scientists at the Salk Institute in La Jolla found that a  “microprotein”  in mouse fat cells plays a critical role in maintaining healthy  mitochondria , the structures that generate energy in our cells. By preserving mitochondrial function, this diminutive protein helps cells burn fuel efficiently, which in turn could influence body weight and the aging process. The findings shine light on how molecular biology connects to everyday health, opening the door to  science-backed strategies for better metabolism and longevity. Mature brown fat cells from a mouse, with the newly discovered microprotein shown in red inside mitochondria (green) and nuclei in blue. This tiny protein helps preserve mitochondrial health under stress. (Credit: Salk Institute) Mighty Mitochondria in ...

Jumping insects like froghoppers use archery techniques

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Froghoppers, also known as spittlebugs, are the champion insect jumpers, capable of reaching heights of 700 mm - more than 100 times their own body length. New research reveals that they achieve their prowess by flexing bow-like structures between their hind legs and wings and releasing the energy in one giant leap in a catapult-like action. Froghoppers are well distributed around the world. Images of the insects flexing and jumping are described in the research carried out by Malcolm Burrows from the University of Cambridge and his colleagues. Burrows' research focused on determining how the energy generated by the insects' muscles is stored before powering a jump.

He said, "A froghopper stores energy by bending a paired bow-shaped part of its internal skeleton called a 'pleural arch' which is a composite structure made of layers of hard cuticle and a rubbery protein called resilin. When the froghopper contracts its muscles to jump, these arches flex like a composite archery bow, and then on recoil catapult it forwards with a force that can be over 400 times its body mass". There are further parallels with the jumping mechanisms of froghoppers and the design of composite bows used in archery. The composite of a hard and an elastic material means that the skeleton of a froghopper, or an archery bow, can resist damage even if they are bent for a long time. Froghoppers are observed to hold the pleural arch in a bent 'ready position', ready to jump at a moment's notice, and to be able to jump repeatedly without damaging the body.

Still more advantages of using composite structures when storing large amounts of energy are seen when considering the development of these storage structures. Froghopper nymphs live in a protective white foam, the familiar cuckoo spit that appears on plants in spring. These nymphs have no resilin in their pleural arches and don't jump until they complete the lifecycle and develop into adult Froghoppers. Source: BMC Biology/EurekAlert.

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