Small Protein, Big Impact: Microprotein Discovery Offers Hope for Obesity and Aging

on
Researchers have uncovered a tiny but powerful protein that helps keep our cells’ energy factories humming – a discovery that could spark new approaches to tackling obesity and age-related decline. Scientists at the Salk Institute in La Jolla found that a  “microprotein”  in mouse fat cells plays a critical role in maintaining healthy  mitochondria , the structures that generate energy in our cells. By preserving mitochondrial function, this diminutive protein helps cells burn fuel efficiently, which in turn could influence body weight and the aging process. The findings shine light on how molecular biology connects to everyday health, opening the door to  science-backed strategies for better metabolism and longevity. Mature brown fat cells from a mouse, with the newly discovered microprotein shown in red inside mitochondria (green) and nuclei in blue. This tiny protein helps preserve mitochondrial health under stress. (Credit: Salk Institute) Mighty Mitochondria in ...

TRPV1, receptor for pain and spicy foods.

on
The research team led by Dr Theodore G. Wensel, professor of biochemistry and molecular biology at Baylor college of medicine at Houston, using sophisticated equipment, generated the first three dimensional view of the protein that allows one in sensing the hot pepper's heat. TRPV1, the protein makes it possible to feel the real heat and the pain and inflammation related to other medical conditions, and also helps in sensing the spicy foods.This finding helps us in understanding the functional relationship between the nerve cell and the outside stimuli, the heat of chilli powder.

TRPV1 is an ion channel, a tiny pore on the cell membrane that allows chemicals such as calcium to flux in and out. So the feel and pain of the burn is mediated by a TRPV1 channel. Different levels of heat are mediated by different TRP channels. In the past, scientists could measure the activity in the cells but it was unclear what each channel was responding to. Determining which proteins interacted with TRPV1, however, required Wensel's lab to create a purified model. This group was the first to purify a TRPV1 channel and control what goes in and out when the channel opens. The report appears in the current issue of the Proceedings of the National Academy of Sciences. Via BCM.

Comments

Post a Comment