Small Protein, Big Impact: Microprotein Discovery Offers Hope for Obesity and Aging

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Researchers have uncovered a tiny but powerful protein that helps keep our cells’ energy factories humming – a discovery that could spark new approaches to tackling obesity and age-related decline. Scientists at the Salk Institute in La Jolla found that a  “microprotein”  in mouse fat cells plays a critical role in maintaining healthy  mitochondria , the structures that generate energy in our cells. By preserving mitochondrial function, this diminutive protein helps cells burn fuel efficiently, which in turn could influence body weight and the aging process. The findings shine light on how molecular biology connects to everyday health, opening the door to  science-backed strategies for better metabolism and longevity. Mature brown fat cells from a mouse, with the newly discovered microprotein shown in red inside mitochondria (green) and nuclei in blue. This tiny protein helps preserve mitochondrial health under stress. (Credit: Salk Institute) Mighty Mitochondria in ...

Saffron might help in reducing PMS symptoms

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Saffron, a spice known for flavouring Mediterranean cuisine, might also offer an antidote to premenstrual syndrome, a small study suggests. Saffron, the world's most expensive spice, had a long history of non-culinary uses. Traditionally, the spice had been advocated for stomach pain, digestive problems and even depression - with some recent clinical trials suggesting that saffron might in fact aid mild depression. It's thought that the spice might influence depression symptoms via effects on the brain chemical serotonin. Because alterations in serotonin activity were suspected in PMS, a team of Iranian researchers decided to study whether saffron supplements might help relieve these symptoms. Dr M Agha-Hosseini and colleagues at Tehran University of Medical Sciences randomly assigned 50 women to take either saffron capsules or a placebo twice a day over two menstrual cycles. The women, who ranged in age from 20 to 45, had all had PMS symptoms such as cramps, bloating, irritability and fatigue for at least six months.

At the end of the treatment period, three-quarters of the women on saffron capsules reported at least a 50% reduction in their PMS symptoms. That compared with only eight percent of women in the placebo group, the researchers report in the medical journal BJOG. In addition, the researchers found, 60% of the saffron group showed a 50% improvement in depression symptoms, versus one woman in the placebo group.The findings, according to the researchers, supported the idea that saffron might affect serotonin activity - and help alleviate not only depression symptoms, but PMS as well. via News24.

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