Small Protein, Big Impact: Microprotein Discovery Offers Hope for Obesity and Aging

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Researchers have uncovered a tiny but powerful protein that helps keep our cells’ energy factories humming – a discovery that could spark new approaches to tackling obesity and age-related decline. Scientists at the Salk Institute in La Jolla found that a  “microprotein”  in mouse fat cells plays a critical role in maintaining healthy  mitochondria , the structures that generate energy in our cells. By preserving mitochondrial function, this diminutive protein helps cells burn fuel efficiently, which in turn could influence body weight and the aging process. The findings shine light on how molecular biology connects to everyday health, opening the door to  science-backed strategies for better metabolism and longevity. Mature brown fat cells from a mouse, with the newly discovered microprotein shown in red inside mitochondria (green) and nuclei in blue. This tiny protein helps preserve mitochondrial health under stress. (Credit: Salk Institute) Mighty Mitochondria in ...

A moths view, engineers to industry.

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When moths fly at night, their eyes need to capture all the light available. To do this, certain species have evolved nanoscopic structures on the surface of their eyes which allow almost no light to reflect off the surface and hence to escape. Now scientists at MicroBridge, a project at Cardiff University's Manufacturing engineering Centre (MEC), have adopted the model to create an industrial lens for use in a low light environment. The structures on the surface of the new lens are less than 100 nanometres in height (a nanometre is one millionth of a millimetre). They need to be smaller than the wavelength of light to avoid disrupting the light as it enters the lens.

The tiny features of the lens mould were created using the MEC's Focused Ion Beam. The beam uses highly charged atomic particles to machine materials in microscopic detail. Dr Robert Hoyle of the MEC said: "This was a particularly complicated challenge. Not only did the lenses have to be of very precise curvature but the nanoscopic structures on the lens surfaces had to be smaller than the wavelength of light so as to smooth out the sharp refractive index change as the light strikes the surface of the lens. This smoothing of the refractive index reduces the reflectiveness of the lens thus allowing it to capture more light. The end result has a number of highly practical uses for industry."

The research team is now looking at using the lens in optoelectronics and photovoltaic applications in semiconductors, including solar cells, where loss of light is a major problem. The lens also has potential uses in fibre optics, sensors and medical diagnostic devices, a report from Sciencedaily.

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