Small Protein, Big Impact: Microprotein Discovery Offers Hope for Obesity and Aging

Researchers have uncovered a tiny but powerful protein that helps keep our cells’ energy factories humming – a discovery that could spark new approaches to tackling obesity and age-related decline. Scientists at the Salk Institute in La Jolla found that a  “microprotein”  in mouse fat cells plays a critical role in maintaining healthy  mitochondria , the structures that generate energy in our cells. By preserving mitochondrial function, this diminutive protein helps cells burn fuel efficiently, which in turn could influence body weight and the aging process. The findings shine light on how molecular biology connects to everyday health, opening the door to  science-backed strategies for better metabolism and longevity. Mature brown fat cells from a mouse, with the newly discovered microprotein shown in red inside mitochondria (green) and nuclei in blue. This tiny protein helps preserve mitochondrial health under stress. (Credit: Salk Institute) Mighty Mitochondria in ...

Another disaster after katrina, the skin disorders

Four distinct skin disorders were found in construction workers who helped repair buildings after Hurricane Katrina and Hurricane Rita, according to a report in the Archives of Dermatology. Outbreaks of skin diseases frequently occur following hurricanes and flooding, but few of these outbreaks have been thoroughly investigated, according to background information in the article. "Hurricane Katrina made landfall on Aug. 29, 2005, and Hurricane Rita on Sept. 24, 2005. Syndromic surveillance in New Orleans, Louisiana, following these hurricanes indicated that 22 percent of diseases treated were dermatologic conditions (i.e., skin or wound infections and rashes)." Rebecca Noe, M.P.H., at the Centers for Disease Control and Prevention, Atlanta, and colleagues analyzed the results of surveys, skin biopsy specimens and the environmental exposures of 136 civilian construction workers working and living at a New Orleans military base between August 2005 and October 2005. Many of these workers lived in wooden huts and tents with limited sanitation facilities.

"Of 136 workers, 58 reported rash, yielding an attack rate of 42.6 percent," the authors write. Forty-one (70.7 percent) of those who reported a rash were examined for diagnosis. Twenty-seven (65.9 percent) were found to have papular urticaria, a sensitivity reaction to insect bites resulting in solid raised bumps on the skin; eight (19.5 percent) had bacterial folliculitis, an infection causing inflammation around the hair follicles; six (14.6 percent) had fiberglass dermatitis, an irritation and inflammation of the skin from contact with fiberglass; and two (4.9 percent) had brachioradial photodermatitis, an abnormal skin reaction to sunlight causing irritation and burning in the arms.

Workers who were Native American, worked as roofers or slept in huts that had sustained flooding during Hurricane Katrina were more likely to suffer from papular urticaria than other workers. Native American workers were also more likely to develop fiberglass dermatitis than workers of another race. "A suspected mite infestation of flooded housing units is the most plausible hypothesis, although we were unable to identify the arthropod [such as insects, spiders and scorpions] source," the authors conclude. "People working and living in post-hurricane environments where flooding has occurred may be at an increased risk of exposure to arthropods. To reduce dermatologic morbidity, we suggest avoiding flooded areas, fumigating with an acaricide [pesticide], wearing protective clothing and using arthropod repellent", a report from Sciencedaily.

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